Does the software that came with your scanner suck? Is your expensive Nikon film scanner sitting on the shelf because you bought a new computer or upgraded to the latest Windows operating system only to find out that Nikon is still in the dark ages?
If so, check out VueScan by Hamrick Software. It supports 750 flatbed and film scanners, you can try before you buy, and email is answered by Ed Hamrick himself.
Among other things, VueScan includes drivers to handle scanners that have been abandoned by the manufacturer, and it works on Windows (including Vista-64), Mac OS, and Linux.
You can read more about why Ed Hamrick is my hero here.